SUPERNOVA‑600 – Dual-Color Miniature Two-Photon Imaging System for Freely Moving Animals
Expanding the Frontiers of In Vivo Brain Imaging
The SUPERNOVA‑600 is an advanced dual-color two-photon miniature imaging system designed to visualize neural activity in freely behaving animals with exceptional clarity and flexibility. Supporting dual excitation wavelengths and a modular, upgradeable architecture, this state-of-the-art system empowers neuroscientists to simultaneously track complex cellular interactions and dynamic processes with benchtop-level precision—while preserving natural behavior.
Free-Moving Animal Imaging
Key features os Transcend Supernova-600
High-quality Data
The SUPERNOVA‑600 supports multiple femtosecond laser wavelengths (780, 920, and 1030 nm), providing unmatched flexibility in choosing fluorescent indicators. Its optical system delivers high resolution with a large field of view, allowing researchers to capture subcellular structures such as dendritic spines and synapses. Integrated synchronization capabilities enable precise temporal alignment between neural imaging and animal behavior, supporting high-resolution studies of brain function during natural movement.
Integrated and Efficient
Built for modern neuroscience workflows, the system supports simultaneous multi-color imaging through its dual-wavelength excitation and dual-headpiece capability. It is fully compatible with optogenetic tools, allowing for combined stimulation and imaging experiments. The streamlined acquisition and control software ensures smooth operation in multi-modal experimental setups, helping scientists focus on discovery rather than technical complexity.
Stable and Scalable
SUPERNOVA‑600 features a modular design, making it easy to expand or upgrade for future needs. Its robust performance is maintained even under high-load conditions, supporting extended imaging sessions without signal degradation. In addition, remote diagnostics and service options ensure ongoing support and minimal downtime, making it a reliable choice for long-term research projects.
Application Spotlight: Combined Two-Photon Imaging and Optogenetics
The SUPERNOVA‑600 supports simultaneous two-photon imaging and optogenetic stimulation in freely moving animals. Using dual-laser input (e.g. 920 nm for imaging and 635 nm for stimulation), researchers can monitor real-time neural activity while manipulating specific cell types—such as VIP neuron inhibition in the dmPFC—revealing precise, stimulus-linked responses across targeted populations.
Why Choose TRANSCEND SUPERNOVA‑600?
SUPERNOVA‑600 offers simultaneous dual-color imaging, making it ideal for studying interactions between distinct neural populations or signaling pathways. Its high-resolution optics detect fine-scale neural structures and capture rapid activity changes with precision. Integrated 3D functionality through an electrically tunable lens allows real-time volumetric imaging across cortical layers. Despite its advanced capabilities, the head-mounted device remains lightweight (~3.3 g), ensuring minimal disruption to natural animal behavior. Thanks to its modular construction and compatibility with a wide range of imaging setups and indicators, SUPERNOVA‑600 adapts seamlessly to diverse experimental demands.
Take your in vivo imaging to the next level.
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